Improving Reproducibility in Toxicology
نویسندگان
چکیده
منابع مشابه
Data quality in predictive toxicology: reproducibility of rodent carcinogenicity experiments.
We compared 121 replicate rodent carcinogenicity assays from the two parts (National Cancer Institute/National Toxicology Program and literature) of the Carcinogenic Potency Database (CPDB) to estimate the reliability of these experiments. We estimated a concordance of 57% between the overall rodent carcinogenicity classifications from both sources. This value did not improve substantially when...
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The concept of reproducibility is one of the foundations of scientific practice and the bedrock by which scientific validity can be established. However, the extent to which reproducibility is being achieved in the sciences is currently under question. Several studies have shown that much peer-reviewed scientific literature is not reproducible. One crucial contributor to the obstruction of repr...
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BACKGROUND The ability to replicate an entire experiment is crucial to the scientific method. With the development of more and more complex paradigms, and the variety of analysis techniques available, fMRI studies are becoming harder to reproduce. RESULTS In this article, we aim to provide practical advice to fMRI researchers not versed in computing, in order to make studies more reproducible...
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Transcriptomic experiments are often used in neuroscience to identify candidate genes of interest for further study. However, the lists of genes identified from comparable transcriptomic studies often show limited overlap. One approach to addressing this issue of reproducibility is to combine data from multiple studies in the form of a meta-analysis. Here, we discuss recent work in the field of...
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Diagnostic DNA hybridization relies on probes composed of single copy (sc) genomic sequences. Sc sequences in probe design ensure high specificity and avoid cross-hybridization to other regions of the genome, which could lead to ambiguous results that are difficult to interpret. We examine how the distribution and composition of repetitive sequences in the genome affects sc probe performance. A...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2014
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfu050